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Oral Ibuprofen for PDA in ELGANs by Afrizal Muhyiddin is a document available to read on EtoBox.
This retrospective analysis investigates the pharmacokinetics and exposure-response relationship of oral ibuprofen in extremely low gestational age neonates (ELGANs) with persistent patent ductus arteriosus (PDA). The study compares standard-dose (SD) and high-dose (HD) regimens, finding comparable exposure levels in both groups, but noting adverse events such as gastrointestinal issues and intraventricular hemorrhage. Further research is needed to explore the PNA-dependent response and optimize dosing stra
- Author
- Afrizal Muhyiddin
- Language
- EN