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Cell Surface Engineering and Application in Cell Delivery to Heart Diseases by Daniel Y. Lee; Byung-Hyun Cha; Minjin Jung; Angela S. Kim; David A. Bull; Young-Wook Won is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Cell Surface Engineering and Application in Cell Delivery to Heart Diseases about?

Cell-based therapy has expanded its influence in cancer immunotherapy, regenerative medicine, and tissue engineering. Due to their secretory functions, differentiation capabilities, specific homing effects through chemotaxis, distinctive therapeutic potentials, and ex vivo expandability, cells have become an attractive reagent for advanced therapeutic strategies. Therefore, the ability to modify cells and manipulate their functions according to intended therapeutic designs has been the central scientific interest in the field of biomedical research. Many innovative methods have been developed with genetic modification of cells being the most advanced cell surface engineering technique. Although genetic modification is a powerful tool, it has a limited applicability due to the permanent modifications made on cells. Alternatively, many endeavors have been made to develop surface engineering techniques that can circumvent the limitations of genetic modification. In this review, current methods of non-genetic cell surface modification, including chemical conjugations, polymeric encapsulation, hydrophobic insertion, enzymatic and metabolic addition, will be introduced. Moreover, cell su

Who reads Cell Surface Engineering and Application in Cell Delivery to Heart Diseases?

Author

Daniel Y. Lee; Byung-Hyun Cha; Minjin Jung; Angela S. Kim; David A. Bull; Young-Wook Won

Publisher

Springer Science and Business Media LLC

Published

2018

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)