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Early-Life Events, Including Mode of Delivery and Type of Feeding, Siblings and Gender, Shape the Developing Gut Microbiota by Rocio Martin; Hiroshi Makino; Aysun Cetinyurek Yavuz; Kaouther Ben-Amor; Mieke Roelofs; Eiji Ishikawa; Hiroyuki Kubota; Sophie Swinkels; Takafumi Sakai; Kenji Oishi; Akira Kushiro; Jan Knol is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Early-Life Events, Including Mode of Delivery and Type of Feeding, Siblings and Gender, Shape the Developing Gut Microbiota about?

Colonization of the infant gut is believed to be critically important for a healthy growth as it influences gut maturation, metabolic, immune and brain development in early life. Understanding factors that influence this process is important, since an altered colonization has been associated with a higher risk of diseases later in life. Fecal samples were collected from 108 healthy neonates in the first half year of life. The composition and functionality of the microbiota was characterized by measuring 33 different bacterial taxa by qPCR/RT qPCR, and 8 bacterial metabolites. Information regarding gender, place and mode of birth, presence of siblings or pets; feeding pattern and antibiotic use was collected by using questionnaires. Regression analysis techniques were used to study associations between microbiota parameters and confounding factors over time. Bacterial DNA was detected in most meconium samples, suggesting bacterial exposure occurs in utero. After birth, colonization by species of Bifidobacterium, Lactobacillus and Bacteroides was influenced by mode of delivery, type of feeding and presence of siblings, with differences found at species level and over time. Interestin

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Author

Rocio Martin; Hiroshi Makino; Aysun Cetinyurek Yavuz; Kaouther Ben-Amor; Mieke Roelofs; Eiji Ishikawa; Hiroyuki Kubota; Sophie Swinkels; Takafumi Sakai; Kenji Oishi; Akira Kushiro; Jan Knol

Publisher

Public Library of Science (PLoS)

Published

2016

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)