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Title: Vincristine-Induced Vocal Cord Paresis and Paralysis in Children by Zavala, Hanan; Roby, Brianne Barnett; Day, Andrew; Bostrom, Bruce; Sidman, James; Chinnadurai, Sivakumar is a Medicine article available to read on EtoBox.

What is Title: Vincristine-Induced Vocal Cord Paresis and Paralysis in Children about?

## Objectives: To describe three new cases of vincristine-induced vocal cord paresis or paralysis (vivcpp) in children and to review the diagnosis and management of this neuropathy. ## Methods: Retrospective case series. diagnosis of vivcpp was confirmed by laryngoscopy in all children. ## Results: Less than 20 cases of vivcpp in children have been previously documented in the literature. of the three children in our case series, one had unilateral vincristine-induced vocal cord paresis and two had bilateral vivcpp. the first two patients each had two separate episodes of paresis, lasting 4 months and 1 month respectively. in the last patient, whose medical course was complicated by many additional factors, vocal cord paralysis persisted for over three years. ## Conclusions: Clinicians must evaluate children with suspected vivcpp for concomitant symptoms and signs of vincristine neuropathies and examine the vocal cords via laryngoscopy. the effects of vincristine neurotoxicity can be waxing and waning, demonstrate delayed onset and persist well beyond drug cessation. further studies are needed to identify effective neuroprotectants and delineate appropriate vincristine dosing in pa

Who reads Title: Vincristine-Induced Vocal Cord Paresis and Paralysis in Children?

Author

Zavala, Hanan; Roby, Brianne Barnett; Day, Andrew; Bostrom, Bruce; Sidman, James; Chinnadurai, Sivakumar

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0165-5876)

Published

2019

Language

EN

Field

Medicine (Health Sciences)