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Haplotype-based association analysis of the MAPT locus in Late Onset Alzheimer's disease by Odity Mukherjee; John SK Kauwe; Kevin Mayo; John C Morris; Alison M Goate is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Haplotype-based association analysis of the MAPT locus in Late Onset Alzheimer's disease about?
## Background Late onset Alzheimer's disease (LOAD) is a common sporadic form of the illness, affecting individuals above the age of 65 yrs. A prominent hypothesis for the aetiopathology of Alzheimer's disease is that in the presence of a β-amyloid load, individuals expressing a pathogenic form of tau protein (__MAPT__) are at increased risk for developing the disease. Genetic studies in this pursuit have, however, yielded conflicting results. A recent study showed a significant haplotype association (H1c) with AD. The current study is an attempt to replicate this association in an independently ascertained cohort. ## Results In this report we present the findings of a haplotype analysis at the __MAPT__ locus. We failed to detect evidence of association of the H1c haplotype at the __MAPT__ locus with LOAD. None of the six SNPs forming the H1c haplotype showed evidence of association with disease. In addition, nested clade analysis suggested the presence of independent mutations at multiple points in the haplotype network or homoplasy at the __MAPT__ locus. Such homoplasy can confound single SNP tests for association. We do not detect evidence that the set of SNPs forming the H1c ha
Who reads Haplotype-based association analysis of the MAPT locus in Late Onset Alzheimer's disease?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Odity Mukherjee; John SK Kauwe; Kevin Mayo; John C Morris; Alison M Goate
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2000-; Springer Science and Business Media LLC (ISSN 1471-2156)
- Published
- 2007
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)