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Effects of poly(lactic‐\ \ co\ \ ‐glycolic acid) (PLGA) degradability on the apatite‐forming capacity of electrospun PLGA/SiO~2~–CaO nonwoven composite fabrics by In Ae Kim; Sang‐Hoon Rhee is a Medicine article available to read on EtoBox.
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## Abstract We investigated the effects of poly(lactic‐__co__‐glycolic acid) (PLGA) degradability on the apatite‐forming ability of electrospun PLGA/SiO~2~–CaO gel composite fabric. Two PLGA copolymer compositions with low and high degradability were used in experiments. A nonwoven polymer/ceramic composite fabric composed of randomly mixed microsized biodegradable PLGA fibers and nanosized bioactive SiO~2~–CaO gel fibers was prepared using a simultaneous electrospinning method. A 17 wt.% PLGA solution was prepared using 1,1,3,3‐hexafluoro‐2‐propanol as a solvent, while the SiO~2~–CaO gel solution was prepared via a condensation reaction following hydrolysis of tetraethyl orthosilicate under acidic conditions. PLGA and SiO~2~–CaO gel solutions were spun simultaneously with two separate nozzles under electric fields of 1 and 2 kV/cm using two syringe pumps with flow rates of 7.5 and 5 mL/h, respectively. As controls, low and high degradable PLGA and SiO~2~–CaO gel nonwoven fabrics were also made by the same methods. The five nonwoven fabrics that were produced were exposed to simulated body fluid (SBF) for 1 week. SBF exposure resulted in the deposition of a layer of apatite crystal
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- Author
- In Ae Kim; Sang‐Hoon Rhee
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1552-4973)
- Published
- 2010
- Language
- EN
- Field
- Medicine (Health Sciences)