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Can I read Tumor cell-activated “Sustainable ROS Generator” with homogeneous intratumoral distribution property for improved anti-tumor therapy on EtoBox?
Tumor cell-activated “Sustainable ROS Generator” with homogeneous intratumoral distribution property for improved anti-tumor therapy by Junjie Liu; Xiu Zhao; Weimin Nie; Yue Yang; Chengcheng Wu; Wei Liu; Kaixiang Zhang; Zhenzhong Zhang; Jinjin Shi is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Tumor cell-activated “Sustainable ROS Generator” with homogeneous intratumoral distribution property for improved anti-tumor therapy about?
Photodynamic therapy (PDT) holds a number of advantages for tumor therapy. However, its therapeutic efficiency is limited by non-sustainable reactive oxygen species (ROS) generation and heterogeneous distribution of photosensitizer (PS) in tumor. Herein, a "Sustainable ROS Generator" (SRG) is developed for efficient antitumor therapy. Methods: SRG was prepared by encapsulating small-sized Mn3O4-Ce6 nanoparticles (MC) into dendritic mesoporous silica nanoparticles (DMSNs) and then enveloped with hyaluronic acid (HA). Due to the high concentration of HAase in tumor tissue, the small-sized MC could be released from DMSNs and homogeneously distributed in whole tumor. Then, the released MC would be uptaken by tumor cells and degraded by high levels of intracellular glutathione (GSH), disrupting intracellular redox homeostasis. More importantly, the released Ce6 could efficiently generate singlet oxygen ( 1 O2) under laser irradiation until the tissue oxygen was exhausted, and the manganese ion (Mn 2+ ) generated by degraded MC would then convert the low toxic by-product (H2O2) of PDT to the most harmful ROS (•OH) for sustainable and recyclable ROS generation. Results: MC could be homoge
Who reads Tumor cell-activated “Sustainable ROS Generator” with homogeneous intratumoral distribution property for improved anti-tumor therapy?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Junjie Liu; Xiu Zhao; Weimin Nie; Yue Yang; Chengcheng Wu; Wei Liu; Kaixiang Zhang; Zhenzhong Zhang; Jinjin Shi
- Publisher
- Ivyspring International Publisher
- Published
- 2021
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)