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Fabrication of Nanofiber Reinforced Protein Structures for Tissue Engineering by Vince Beachley; Xuejun Wen is a Engineering article available to read on EtoBox.

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Extracellular matrices and degradable nanofibers are two very promising materials in the field of tissue engineering; however both of these structures face limitations as tissue engineering scaffolds. Extracellular matrices, such as collagen, gelatin, laminin, have excellent biocompatibility and allow cell in growth and survival, but structural weakness makes them difficult to handle and greatly limits their uses. Degradable nanofibers support cell attachment and can provide structural support and directional guidance, but individual degradable nanofibers are fragile and have a tendency to form dense fiber bundles which limited the cell penetration into the spaces between the nanofibers, especially in the case of aligned nanofibers. To overcome these difficulties, degradable loose nanofibers were embedded in protein matrix in an attempt to fabricate a hybrid scaffold with improved properties, such as improved strength, guidance, spacing among nanofibers, etc.. Polycaprolactone (PCL) was used as a model material for degradable nanofibers. Gelatin was employed as a model protein for matrix structure formation. Thin hybrid films (average thickness = 2.78 um) were fabricated by wetting

Who reads Fabrication of Nanofiber Reinforced Protein Structures for Tissue Engineering?

Author

Vince Beachley; Xuejun Wen

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0928-4931)

Published

2009

Language

EN

Field

Engineering (Physical Sciences)