Opening book details…
Can I read Multilayered Human Skeletal Muscle Myoblast Sheets Promote the Healing Process After Colonic Anastomosis in Rats on EtoBox?
Multilayered Human Skeletal Muscle Myoblast Sheets Promote the Healing Process After Colonic Anastomosis in Rats by Takashi Nakamura; Utako Yokoyama; Tomomitsu Kanaya; Takayoshi Ueno; Takanori Yoda; Atsushi Ishibe; Yuko Hidaka; Masanari Umemura; Toshio Takayama; Makoto Kaneko; Shigeru Miyagawa; Yoshiki Sawa; Itaru Endo; Yoshihiro Ishikawa is a Medicine article available to read on EtoBox.
What is Multilayered Human Skeletal Muscle Myoblast Sheets Promote the Healing Process After Colonic Anastomosis in Rats about?
Colorectal anastomotic leakage is one of the most feared and fatal complications of colorectal surgery. To date, no external coating material that can prevent anastomotic leakage has been developed. As myoblasts possess anti-inflammatory capacity and improve wound healing, we developed a multilayered human skeletal muscle myoblast (HSMM) sheet by periodic exposure to supraphysiological hydrostatic pressure during repeated cell seeding. We assessed whether the application of an HSMM sheet can promote the healing process after colonic anastomosis. Partial colectomy and insufficient suturing were employed to create a high-risk colo-colonic anastomosis model in 60 nude rats. Rats were divided into a control group (__n__ = 30) and an HSMM sheet group (__n__ = 30). Macroscopic findings, anastomotic bursting pressure, and histology at the colonic anastomotic site were evaluated on postoperative day (POD) 3, 5, 7, 14, and 28. The application of an HSMM sheet significantly suppressed abscess formation at the anastomotic site compared to the control group on POD3 and 5. The anastomotic bursting pressure in the HSMM sheet group was higher than that in the control group on POD3 and 5. Inflamma
Who reads Multilayered Human Skeletal Muscle Myoblast Sheets Promote the Healing Process After Colonic Anastomosis in Rats?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Takashi Nakamura; Utako Yokoyama; Tomomitsu Kanaya; Takayoshi Ueno; Takanori Yoda; Atsushi Ishibe; Yuko Hidaka; Masanari Umemura; Toshio Takayama; Makoto Kaneko; Shigeru Miyagawa; Yoshiki Sawa; Itaru Endo; Yoshihiro Ishikawa
- Publisher
- SAGE Publications
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)