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APOE genotype predicts depression in women with Alzheimer's disease: a retrospective study by Lisa Delano-Wood; Wes S. Houston; Jennifer A. Emond; Natalie L. Marchant; David P. Salmon; Dilip V. Jeste; Leon J. Thal; Mark W. Bondi is a Medicine article available to read on EtoBox.
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## Abstract ## Objective The association between the APOE __ε__4 allele and depression was investigated in a retrospective study of 323 AD patients. ## Methods Patients were divided into demographically comparable groups based on the presence or absence of depression. ## Results Results showed that the frequency of APOE __ε__4 allele was significantly higher in the depressed __vs__ non‐depressed AD patients (72% and 58%, respectively), and an interaction revealed that women possessing the APOE __ε__4 allele were almost four times more likely to be depressed than those without the __ε__4 allele. ## Conclusion Results are consistent with recent suggestions that the APOE __ε__4 genotype may be over‐represented among depressed women with AD and highlight the need for additional research investigating the links between APOE genotype, mood, and gender. Copyright © 2007 John Wiley & Sons, Ltd.
Who reads APOE genotype predicts depression in women with Alzheimer's disease: a retrospective study?
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- Author
- Lisa Delano-Wood; Wes S. Houston; Jennifer A. Emond; Natalie L. Marchant; David P. Salmon; Dilip V. Jeste; Leon J. Thal; Mark W. Bondi
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0885-6230)
- Published
- 2007
- Language
- EN
- Field
- Medicine (Health Sciences)