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Letter to the Editor: Long-term experience in treating autoimmune hepatitis with acute presentation by Keiichi Fujiwara; Shin Yasui; Takayuki Kondo; Osamu Yokosuka; Naoya Kato is a Medicine article available to read on EtoBox.

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who reviewed clinical, laboratory and histological data of acute liver failure (ALF) due to autoimmune hepatitis (AIH) enrolled in the ALF Study Group Registry between 1998 and 2019 in the United States and identified variables that predict 21-day transplant-free survival.We applaud their efforts for treating this rare and life-threatening syndrome.From over a 20-year review, we could have a high short-term mortality of AIH-ALF reconfirmed, in the US as well as in Japan . We also understand analyses of incomplete nationwide data by the Adjudication Committee are complicated, as authors described.Difficulty in discussing AIH with acute presentation would largely depend on the lack of the clear definition of itself and the disease severity, which should be resolved in the future. The definitions have been different among most studies.What is the most important strategy for difficult-to-diagnose and difficult-to-treat liver diseases like acute AIH is to diagnose and treat "non-severe" disease before developing into severe disease, therefore, we have analyzed various aspects of non-severe acute AIH patients. In our recent analysis of acute AIH, 69% of non-severe acute AIH patients had

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Author

Keiichi Fujiwara; Shin Yasui; Takayuki Kondo; Osamu Yokosuka; Naoya Kato

Publisher

Ovid Technologies (Wolters Kluwer Health)

Published

2023

Language

EN

Field

Medicine (Health Sciences)