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Inborn Errors of Immunity in Children With Invasive Pneumococcal Disease: A Multicenter Prospective Study by Linny Kimly Phuong; Abigail Cheung; Rishi Agrawal; Coen Butters; Jim Buttery; Julia Clark; Tom Connell; Nigel Curtis; Andrew J. Daley; Hazel C. Dobinson; Catherine Frith; Nadha Shahul Hameed; Hayley Hernstadt; David M. Krieser; Paxton Loke; Samar Ojaimi; Brendan McMullan; Alberto Pinzon-Charry; Ella Grace Sharp; Praisoody Sinnappurajar; Tiarni Templeton; Sophie Wen; Theresa Cole; Amanda Gwee is a Medicine article available to read on EtoBox.

What is Inborn Errors of Immunity in Children With Invasive Pneumococcal Disease: A Multicenter Prospective Study about?

## Background: In settings with universal conjugate pneumococcal vaccination, invasive pneumococcal disease (IPD) can be a marker of an underlying inborn error of immunity. The aim of this study was to determine the prevalence and characterize the types of immunodeficiencies in children presenting with IPD. ## Methods: Multicenter prospective audit following the introduction of routinely recommended immunological screening in children presenting with IPD. The minimum immunological evaluation comprised a full blood examination and film, serum immunoglobulins (IgG, IgA and IgM), complement levels and function. Included participants were children in whom Streptococcus pneumoniae was isolated from a normally sterile site (cerebrospinal fluid, pleura, peritoneum and synovium). If isolated from blood, features of sepsis needed to be present. Children with predisposing factors for IPD (nephrotic syndrome, anatomical defect or malignancy) were excluded. ## Results: Overall, there were 379 episodes of IPD of which 313 (83%) were eligible for inclusion and 143/313 (46%) had an immunologic evaluation. Of these, 17/143 (12%) were diagnosed with a clinically significant abnormality: hypogammagl

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Author

Linny Kimly Phuong; Abigail Cheung; Rishi Agrawal; Coen Butters; Jim Buttery; Julia Clark; Tom Connell; Nigel Curtis; Andrew J. Daley; Hazel C. Dobinson; Catherine Frith; Nadha Shahul Hameed; Hayley Hernstadt; David M. Krieser; Paxton Loke; Samar Ojaimi; Brendan McMullan; Alberto Pinzon-Charry; Ella Grace Sharp; Praisoody Sinnappurajar; Tiarni Templeton; Sophie Wen; Theresa Cole; Amanda Gwee

Publisher

Ovid Technologies (Wolters Kluwer Health)

Published

2023

Language

EN

Field

Medicine (Health Sciences)