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Can I read Rational Design, Synthesis, in Vitro , and in Silico Studies of Chlorophenylquinazolin‐4(3 H )‐One Containing Different Aryl Acetohydrazides as Tyrosinase Inhibitors on EtoBox?
Rational Design, Synthesis, in Vitro , and in Silico Studies of Chlorophenylquinazolin‐4(3 H )‐One Containing Different Aryl Acetohydrazides as Tyrosinase Inhibitors by Mirhamed Hajimiri; Mohammad Khosravikia; Mehdi Khoshneviszadeh; Keyvan Pedrood; Seyedeh Zahra Hosseini; Mohammad Sadegh Asgari; Somayeh Pirhadi; Mahshid Attarroshan; Koroush Mobaraki; Samanesadat Hosseini; Hossein Behnammanesh; Mahmood Biglar; Somayeh Karimian; Hossein Rastegar; Haleh Hamedifar; Bagher Larijani; Mohammad Mahdavi; Aida Iraji is a Agricultural and Biological Sciences article available to read on EtoBox.
What is Rational Design, Synthesis, in Vitro , and in Silico Studies of Chlorophenylquinazolin‐4(3 H )‐One Containing Different Aryl Acetohydrazides as Tyrosinase Inhibitors about?
Tyrosinase plays a pivotal role in the hyperpigmentation and enzymatic browning of fruit and vegetable. Therefore, tyrosinase inhibitors can be of interest in industries as depigmentation compounds as well as anti-browning agents. In the present study, a series of chlorophenylquinazolin-4(3H)-one derivative were rationally designed and synthesized. The formation of target compounds was confirmed by spectral characterization techniques such as IR, H-NMR, C-NMR, and elemental analysis. Among the synthesized derivatives, compound 8l was proved to be the most potent inhibitor with an IC value of 25.48±1.19 μM. Furthermore, the results of the molecular docking study showed that this compound fitted well in the active site of tyrosinase with the binding score of -10.72.
Who reads Rational Design, Synthesis, in Vitro , and in Silico Studies of Chlorophenylquinazolin‐4(3 H )‐One Containing Different Aryl Acetohydrazides as Tyrosinase Inhibitors?
It is typically read by researchers, students, and practitioners in Agricultural and Biological Sciences.
- Author
- Mirhamed Hajimiri; Mohammad Khosravikia; Mehdi Khoshneviszadeh; Keyvan Pedrood; Seyedeh Zahra Hosseini; Mohammad Sadegh Asgari; Somayeh Pirhadi; Mahshid Attarroshan; Koroush Mobaraki; Samanesadat Hosseini; Hossein Behnammanesh; Mahmood Biglar; Somayeh Karimian; Hossein Rastegar; Haleh Hamedifar; Bagher Larijani; Mohammad Mahdavi; Aida Iraji
- Publisher
- Wiley
- Published
- 2022
- Language
- EN
- Field
- Agricultural and Biological Sciences (Life Sciences)