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Meta-analysis of the association between RNF213 polymorphisms and clinical features of moyamoya disease in Asian population 1 1 Introduction 1 2 Materials and methods 2 2.1 Literature retrieval strategy 2 2.2 Selection criteria and identification of relevant studies 2 2.3 Data extraction 3 2.4 Data synthesis and publication bias 3 2.5 Standard protocol approvals, registrations, and patient consents 3 3 Results 4 3.1 Characteristics of the included studies 4 3.2 Association of RNF213 polymorphisms with gender distribution 4 3.3 Association between RNF213 polymorphism and clinical features of MMD 4 3.4 Association of RNF213 polymorphisms with age at onset 4 3.5 Correlation of RNF213 polymorphisms with family history in clinical features of the MMD 4 3.6 RNF213 polymorphisms associated with cerebral stroke 4 3.7 Association between RNF213 polymorphisms and angiographic findings 5 3.8 Publication bias 5 4 Discussion 6 4.1 Limitations 6 5 Conclusions 6 Conflicts of interest 6 Funding 6 CRediT authorship contribution statement 6 Appendix A Supporting information 6 References 6

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EN

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nonfiction