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This study investigates the gene expression of virulence factors in Streptococcus pneumoniae variants during infection of human middle ear epithelial cells under simulated conditions. The transparent (T) variant shows increased expression of virulence genes compared to the opaque (O) variant, particularly in environments mimicking Eustachian tube obstruction. The findings suggest that the T variant is more adept at colonizing the middle ear and plays a significant role in the pathogenesis of pneumococcal ot

Author

Ana Paula de Mattos Areas Dau

Language

EN