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Membrane Proteomics: Methods and Protocols (Methods in Molecular Biology, 528) by Matthew J. Peirce (editor), Robin Wait (editor) is a nonfiction available to read on EtoBox.

What is Membrane Proteomics: Methods and Protocols (Methods in Molecular Biology, 528) about?

The membranes surrounding cells and organelles constitute their interface with the local environment. The functions of membrane proteins include cell/cell and cell/extracellular matrix recognition, the reception and transduction of extracellular signals, and the tra- port of proteins, solutes and water molecules. Abnormal membrane protein expression has profound biological effects and may, for example, underlie phenotypic and functional differences between normal and tumour cells. Moreover the accessibility, particularly of plasma proteins traversing the plasma membrane of cells, makes them of particular ut- ity to the therapeutic intervention in disease. Indeed, it is estimated that of all currently licensed pharmaceuticals, approximately 70% target proteins resident in the plasma m- brane. In theory, unbiased technologies such as proteomics have the power to de?ne patterns of membrane protein expression characteristic of distinct states of cellular development, differentiation or disease, and thereby identify novel markers of, or targets for intervention in, disease. However, although about 25% of open reading frames in fully sequenced genomes are estimated to encode integral mem

Who reads Membrane Proteomics: Methods and Protocols (Methods in Molecular Biology, 528)?

Author

Matthew J. Peirce (editor), Robin Wait (editor)

Publisher

Humana Press : Imprint : Humana

Published

2009

Language

EN

ISBN

9781603273107

Category

nonfiction

Subjects

Science, Chemistry, Medical