Can I read Development and Degeneration of the Intervertebral Disc—Insights from Across Species on EtoBox?

Development and Degeneration of the Intervertebral Disc—Insights from Across Species by Kathryn Murphy; Thomas Lufkin; Petra Kraus is a Agricultural and Biological Sciences article available to read on EtoBox.

What is Development and Degeneration of the Intervertebral Disc—Insights from Across Species about?

## Simple Summary The intervertebral disc is an important organ providing structure, support and flexibility to the spine, yet it can degrade over an individual’s lifetime resulting in a painful condition known as intervertebral disc degeneration. Historically, the degeneration or breakdown of the organ has been catalogued and studied in humans, mice and to some extent dogs, however research has expanded to rats, cows, horses, rabbits, cats, and monkeys in recent decades allowing for the application of new research methods. Expanded research has further clarified the mechanisms contributing to degeneration at a molecular and cellular level. This review examines stressors promoting degeneration, how the intervertebral disc responds to them, the variation in symptomatic presentation of intervertebral disc degeneration between species, physical differences in the disc at different levels in the spine and between animals, as well as how the cellular population of the disc changes over time. Examining these aspects both within and between species helps to characterize degenerative changes in the intervertebral disc necessary for development of treatment and therapy. ## Abstract Back pai

Who reads Development and Degeneration of the Intervertebral Disc—Insights from Across Species?

Author

Kathryn Murphy; Thomas Lufkin; Petra Kraus

Publisher

MDPI AG

Published

2023

Field

Agricultural and Biological Sciences (Life Sciences)