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Nucleotide‐induced Ca^2+^ signaling in sustentacular supporting cells of the olfactory epithelium by Thomas Hassenklöver; Silvia Kurtanska; Ilonka Bartoszek; Stephan Junek; Detlev Schild; Ivan Manzini is a Neuroscience article available to read on EtoBox.
What is Nucleotide‐induced Ca^2+^ signaling in sustentacular supporting cells of the olfactory epithelium about?
Extracellular purines and pyrimidines are important signaling molecules acting via purinergic cell-surface receptors in neurons, glia, and glia-like cells such as sustentacular supporting cells (SCs) of the olfactory epithelium (OE). Here, we thoroughly characterize ATP-induced responses in SCs of the OE using functional Ca 21 imaging. The initial ATP-induced increase of the intracellular Ca 21 concentration [Ca 21 ] i always occurred in the apical part of SCs and subsequently propagated toward the basal lamina, indicating the occurrence of purinergic receptors in the apical part of SCs. The mean propagation velocity of the Ca 21 signal within SCs was 17.10 6 1.02 lm/s. ATP evoked increases in [Ca 21 ] i in both the presence and absence of extracellular Ca 21 . Depletion of the intracellular Ca 21 stores abolished the responses. This shows that the ATP-induced [Ca 21 ] i increases were in large part, if not entirely, due to the activation of G protein-coupled receptors followed by Ca 21 mobilization from intracellular stores, suggesting an involvement of P2Y receptors. The order of potency of the applied purinergic agonists was UTP > ATP > ATPgS (with all others being only weakly a
Who reads Nucleotide‐induced Ca^2+^ signaling in sustentacular supporting cells of the olfactory epithelium?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Thomas Hassenklöver; Silvia Kurtanska; Ilonka Bartoszek; Stephan Junek; Detlev Schild; Ivan Manzini
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0894-1491)
- Published
- 2008
- Language
- EN
- Field
- Neuroscience (Life Sciences)