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Clinical Outcomes of Patients with Giant Cell Arteritis Treated with Tocilizumab in Real-world Clinical Practice: Decreased Incidence of New Visual Manifestations by Sebastian Unizony; Timothy J. McCulley; Robert Spiera; Jinglan Pei; Paris N. Sidiropoulos; Jennie H. Best; Christine Birchwood; Andrey Pavlov; John H. Stone is a Medicine article available to read on EtoBox.
What is Clinical Outcomes of Patients with Giant Cell Arteritis Treated with Tocilizumab in Real-world Clinical Practice: Decreased Incidence of New Visual Manifestations about?
## Abstract ## Background Placebo-controlled clinical trials have demonstrated the efficacy of tocilizumab (TCZ) for remission maintenance and glucocorticoid sparing in patients with giant cell arteritis (GCA). However, limited data exist on the effectiveness and safety of TCZ for GCA in real-world clinical practice. ## Methods This was a retrospective, single-center analysis of patients with GCA treated with intravenous or subcutaneous TCZ (2010–2018). Outcomes evaluated before and after TCZ initiation included occurrence of flare, time to flare, annualized flare rate, flare characteristics (i.e., polymyalgia rheumatica [PMR] symptoms, cranial manifestations), prednisone use, and safety. Flare was defined as the recurrence of unequivocal GCA manifestations requiring treatment intensification. Subgroup analyses of patients with PMR or visual manifestations at GCA diagnosis were performed. ## Results Sixty patients with GCA were included. The median (IQR) disease duration before and after the start of TCZ was 0.6 (0.2–1.6) and 0.5 (0.3–1.4) years, respectively. At least 1 flare was observed in 43 patients (71.7%) before and in 18 (30.0%) after TCZ initiation. Median (IQR) time to fl
Who reads Clinical Outcomes of Patients with Giant Cell Arteritis Treated with Tocilizumab in Real-world Clinical Practice: Decreased Incidence of New Visual Manifestations?
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- Author
- Sebastian Unizony; Timothy J. McCulley; Robert Spiera; Jinglan Pei; Paris N. Sidiropoulos; Jennie H. Best; Christine Birchwood; Andrey Pavlov; John H. Stone
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)