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Can I read Early high peak hepatitis C viral load levels independently predict hepatitis C-related liver failure post-liver transplantation: Early High Peak Hepatitis C Viral Load Levels on EtoBox?
Early high peak hepatitis C viral load levels independently predict hepatitis C-related liver failure post-liver transplantation: Early High Peak Hepatitis C Viral Load Levels by Nicholas A. Shackel; Jade Jamias; Wassim Rahman; Emilia Prakoso; Simone I. Strasser; David J. Koorey; Michael D. Crawford; Deborah J. Verran; James Gallagher; Geoffrey W. McCaughan is a Medicine article available to read on EtoBox.
What is Early high peak hepatitis C viral load levels independently predict hepatitis C-related liver failure post-liver transplantation: Early High Peak Hepatitis C Viral Load Levels about?
The aim of this study was to examine the importance of the serum hepatitis C viral load within the first year post-liver transplant in determining posttransplant survival. A retrospective analysis of 118 consecutive hepatitis C virus-positive liver transplant recipients who received an allograft from January 1997 to September 2005 was undertaken with a median duration of follow-up of 32.4 months. Univariate and multivariate analyses were used to examine the effects of recipient, donor, surgical, and viral factors on posttransplant outcomes. A total of 620 viral load estimations were undertaken in the first 12 months following transplantation. Patient and graft survival rates at 1, 3, and 5 years were 87.8%, 79.9%, and 70.1% and 87.0%, 79.2%, and 68.2%, respectively. According to multivariate analysis, a peak viral load Ն 10 7 IU/mL (P ϭ 0.004; hazard ratio, 8.68; 95% confidence interval, 2.04-37.02) and exposure to antirejection therapy (P ϭ 0.05; hazard ratio, 2.26; 95% confidence interval, 1.01-5.38) were both independent predictors of diminished patient and graft survival and hepatitis C-related allograft failure. The only other independent predictor of hepatitis C virus-related
Who reads Early high peak hepatitis C viral load levels independently predict hepatitis C-related liver failure post-liver transplantation: Early High Peak Hepatitis C Viral Load Levels?
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- Author
- Nicholas A. Shackel; Jade Jamias; Wassim Rahman; Emilia Prakoso; Simone I. Strasser; David J. Koorey; Michael D. Crawford; Deborah J. Verran; James Gallagher; Geoffrey W. McCaughan
- Publisher
- Ovid Technologies (Wolters Kluwer Health)
- Published
- 2009
- Language
- EN
- Field
- Medicine (Health Sciences)