Opening book details…
Can I read A mouse model for visualization of GABA~B~ receptors on EtoBox?
A mouse model for visualization of GABA~B~ receptors by Emilio Casanova; Nicole Guetg; Réjan Vigot; Riad Seddik; Marcela Julio‐Pieper; Niall P. Hyland; John F. Cryan; Martin Gassmann; Bernhard Bettler is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is A mouse model for visualization of GABA~B~ receptors about?
GABA B receptors are the G-protein-coupled receptors for the neurotransmitter c-aminobutyric acid (GABA). Receptor subtypes are based on the subunit isoforms GABA B1a and GABA B1b , which combine with GABA B2 subunits to form heteromeric receptors. Here, we used a modified bacterial artificial chromosome (BAC) containing the GABA B1 gene to generate transgenic mice expressing GABA B1a and GABA B1b subunits fused to the enhanced green fluorescence protein (eGFP). We demonstrate that the GABA B1 -eGFP fusion proteins reproduce the cellular expression patterns of endogenous GABA B1 proteins in the brain and in peripheral tissue. Crossing the GABA B1 -eGFP BAC transgene into the GABA B1 2/2
Who reads A mouse model for visualization of GABA~B~ receptors?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Emilio Casanova; Nicole Guetg; Réjan Vigot; Riad Seddik; Marcela Julio‐Pieper; Niall P. Hyland; John F. Cryan; Martin Gassmann; Bernhard Bettler
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1526-954X)
- Published
- 2009
- Language
- DA
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)