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Succinate dehydrogenase (SDH) is a key enzyme in the citric acid cycle that catalyzes the oxidation of succinate to fumarate while transferring electrons to the electron transport chain. Mutations in SDH subunits can lead to various clinical conditions, including Leigh syndrome and certain types of cancer. The document also describes an ultrahistochemical method for detecting SDH activity in tissues using tetrazolium salts as indicators of cell viability.

Author

Mona Abouzied

Language

EN