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Treatment of Experimental Arthritis by Inducing Immune Tolerance with Human Adipose-derived Mesenchymal Stem Cells by Manuel A. González; Elena Gonzalez-Rey; Laura Rico; Dirk Büscher; Mario Delgado is a Medicine article available to read on EtoBox.

What is Treatment of Experimental Arthritis by Inducing Immune Tolerance with Human Adipose-derived Mesenchymal Stem Cells about?

## Abstract ## Objective Rheumatoid arthritis (RA) is a chronic autoimmune disease caused by loss of immunologic self tolerance and characterized by chronic joint inflammation. Adult mesenchymal stem cells (MSCs) were recently found to suppress effector T cell responses and to have beneficial effects in various immune disorders. The purpose of this study was to examine a new therapeutic strategy for RA based on the administration of human adipose‐derived MSCs (AD‐MSCs). ## Methods DBA/1 mice with collagen‐induced arthritis were treated with human AD‐MSCs after disease onset, and clinical scores were determined. Inflammatory response was determined by measuring the levels of different mediators of inflammation in the joints and serum. The Th1‐mediated autoreactive response was evaluated by determining the proliferative response and cytokine profile of draining lymph node cells stimulated with the autoantigen. The number of Treg cells and the suppressive capacity on self‐reactive Th1 cells were also determined. ## Results Systemic infusion of human AD‐MSCs significantly reduced the incidence and severity of experimental arthritis. This therapeutic effect was mediated by down‐regulati

Who reads Treatment of Experimental Arthritis by Inducing Immune Tolerance with Human Adipose-derived Mesenchymal Stem Cells?

Author

Manuel A. González; Elena Gonzalez-Rey; Laura Rico; Dirk Büscher; Mario Delgado

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0004-3591)

Published

2009

Language

EN

Field

Medicine (Health Sciences)