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This study investigates the effects of multiple low-dose streptozotocin (SZ) on hyperglycemia and insulitis in C57BL mice, focusing on the influence of inbred background, sex, and thymus presence. Results indicate that thymectomy does not prevent severe hyperglycemia in males, while females show less susceptibility despite exhibiting insulitis. The findings suggest a complex interplay between direct toxicity and autoimmune responses in the development of diabetes, with implications for understanding type I

Author

n_mladenov

Language

EN