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Kinetics of SuPAR hemoadsorption in critical COVID-19 patients on renal replacement therapy by Vaidas Vicka; Elija Januskeviciute; Ieva Bartuševiciene; Donata Ringaitiene; Aiste Aleknaviciene; Mindaugas Serpytis; Laurynas Rimsevicius; Marius Miglinas; Ligita Jancoriene; Jurate Sipylaite is a Medicine article available to read on EtoBox.

What is Kinetics of SuPAR hemoadsorption in critical COVID-19 patients on renal replacement therapy about?

## Abstract ## Background SARS-CoV-2 viral infection is associated with a rapid and vigorous systemic inflammatory response syndrome. Soluble urokinase-type plasminogen activator receptor (suPAR) is a novel biomarker, both indicative of inflammation and propagating it. Hemoadsorption has been proposed as a potential therapy in COVID-19 patients, therefore the aim of this study is to determine suPAR kinetics during hemoadsoprtion. ## Methods This was a prospective observational study of critical COVID-19 patients, enrolled when hemoperfusion therapy was initiated. Hemoadsorber was integrated into the continuous renal replacement therapy circuit. The first series of suPAR measurements was performed 10 minutes after the start of the session, sampling both incoming and outgoing lines of the adsorber. A second series of the measurements was performed beforefinishing the session with the same adsorber. Statistical significance level was set < 0.05. ## Results This study included 18 patients. In the beginning of the session the fraction of suPAR cleared across the adsorber was 29.5% [16-41], and in the end of the session it decreased to 7.2% [4-22], 4 times lower, p = 0.003. The median le

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Author

Vaidas Vicka; Elija Januskeviciute; Ieva Bartuševiciene; Donata Ringaitiene; Aiste Aleknaviciene; Mindaugas Serpytis; Laurynas Rimsevicius; Marius Miglinas; Ligita Jancoriene; Jurate Sipylaite

Publisher

Springer Science and Business Media LLC

Published

2022

Language

EN

Field

Medicine (Health Sciences)