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Can I read 6-Nitrodopamine is an endogenous selective dopamine receptor antagonist in Chelonoidis carbonaria aorta on EtoBox?
6-Nitrodopamine is an endogenous selective dopamine receptor antagonist in Chelonoidis carbonaria aorta by José Britto-Júnior; Rafael Campos; Matheus Peixoto; Antonio Tiago Lima; Felipe Fernandes Jacintho; Fabíola Z. Mónica; Ronilson Agnaldo Moreno; Edson Antunes; Gilberto De Nucci is a Environmental Science article available to read on EtoBox.
What is 6-Nitrodopamine is an endogenous selective dopamine receptor antagonist in Chelonoidis carbonaria aorta about?
Chelonoidis carbonaria aortic rings present endothelium-derived release of dopamine, noradrenaline, adrenaline and 6-nitrodopamine (6-ND). Here it was investigated whether 6-ND release is coupled to nitric oxide (NO) synthesis and its action on the vascular smooth muscle reactivity. Basal release of 6-ND from aortic rings in the absence and presence of the NO synthesis inhibitor L-NAME was quantified by LC-MS-MS. Aortic rings were suspended vertically between two metal hooks in 10-mL organ baths containing Krebs-Henseleit's solution and attached to isometric transducers. The tissues were allowed to equilibrate for 1 h before starting the experiments. The release of 6-ND was significantly reduced by previous incubation with L-NAME. 6-ND (up to 300 μM) had no contractile activity in the aortic rings. 6-ND (1, 3 and 10 μM) produced significant rightward shifts of the concentration-response curves to dopamine in endothelium-intact (pA 6.09) and L-NAME pre-treated endothelium-intact (pA 7.06) aortic rings. Contractions induced by noradrenaline and adrenaline were not affected by pre-incubation with 6-ND. The EFS (16 Hz)-induced aortic contractions were significantly inhibited by incubat
Who reads 6-Nitrodopamine is an endogenous selective dopamine receptor antagonist in Chelonoidis carbonaria aorta?
It is typically read by researchers, students, and practitioners in Environmental Science.
- Author
- José Britto-Júnior; Rafael Campos; Matheus Peixoto; Antonio Tiago Lima; Felipe Fernandes Jacintho; Fabíola Z. Mónica; Ronilson Agnaldo Moreno; Edson Antunes; Gilberto De Nucci
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Environmental Science (Physical Sciences)