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Can I read Perturbation of Human Skin Due to Application of High Voltage on EtoBox?
Perturbation of Human Skin Due to Application of High Voltage by Uwe F. Pliquett; Christian A. Gusbeth is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Perturbation of Human Skin Due to Application of High Voltage about?
Electroporation is believed to be the effect that greatly enhances the transport of water-soluble molecules across the stratum corneum (SC) by application of short high voltage pulses. However, electroporation was originally a phenomenon investigated at the level of cell and model membranes, which is only partially comparable to the complicated structure of the stratum corneum. Here, we show, that electroporation is accompanied by other effects, which may be primarily involved in creation of new pathways and altering existing pathways, respectively. Experimental evidence shows that the dramatic increase in skin permeability is due to synergistic effect of electric field and heating by high local current density. Heating starts at small spots, not related to a visible skin structure and results in a propagating heat front. The phase transition of the SC lipids plays a major role in skin permeability during the pulse. The permeability after a high voltage pulse correlates well with the surface area showing a permanent low electrical resistance after pulsing. The main transport of water-soluble molecules is facilitated by the electric field due to the electrophoretic driving force in
Who reads Perturbation of Human Skin Due to Application of High Voltage?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Uwe F. Pliquett; Christian A. Gusbeth
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 1567-5394)
- Published
- 2000
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Physical Sciences)