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Growth and biochemical characteristics of a detachment variant of CHO cells by Alan G. Atherly; Benjamin J. Barnhart; Paul M. Kraemer is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract A variant subline of Chinese hamster cells (line CHO) was isolated that had increased resistance to detachment from the substratum. Comparisons between parental and variant cells of the complex carbohydrates liberated during trypsin detachment showed that the variant cells synthesized little or no hyaluronic acid. These cells also had reduced amounts of other complex carbohydrates in the cell periphery. However, parental and variant cells did not differ in morphology, growth control, or cyclic AMP concentration. Profound changes in the physical and chemical nature of the cell periphery, in themselves, evidently are insufficient to cause changes in many aspects of cell behavior.

Who reads Growth and biochemical characteristics of a detachment variant of CHO cells?

Author

Alan G. Atherly; Benjamin J. Barnhart; Paul M. Kraemer

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0021-9541)

Published

1977

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)