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A High-Fiber Diet Decreases Postabsorptive Protein Turnover but Does Not Alter Insulin Sensitivity in Men with Type 1 Diabetes Mellitus by Daniela Bruttomesso; Paolo Tessari is a Medicine article available to read on EtoBox.

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## Background: High-fiber diets (hfds) are recommended in the diet of persons with diabetes, yet such diets can impair macronutrient digestion and/or absorption, modify insulin sensitivity, and reset metabolism. ## Objectives: We studied the effects of a hfd on the kinetics of whole-body protein, a macronutrient that could be affected by dietary fiber, in type 1 diabetes mellitus (t1dm), under both basal-low insulinemic and hyperinsulinemic conditions. ## Methods: Eight men with t1dm (body mass index range: 21.8-27.8 kg/m2) were studied twice - before and after the addition of guar gum (∼15 g/d) to their usual diet for ∼4 mo. whole-body protein degradation (i.e., the rate of appearance [ra] of endogenous leucine), leucine disposal to protein synthesis (ps), deamination, and reamination, were determined before and after the hfd, both in the postabsorptive state and following a euglycemic, hyperinsulinemic, hyperaminoacidemic clamp, using isotope dilution methods. ## Results: After the hfd, mean values (± ses) for postabsorptive leucine ra decreased by ∼20%: from 2.52 (0.15) to 2.03 (0.16) μmol x kg-1 x min-1, p < 0.049, after vs. before the hfd respectively. ps also decreased, by ∼2

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Author

Daniela Bruttomesso; Paolo Tessari

Publisher

Elsevier BV

Published

2019

Language

EN

Field

Medicine (Health Sciences)