Can I read N-Acetamideindolecarboxylic acid allosteric ‘finger-loop’ inhibitors of the hepatitis C virus NS5B polymerase: discovery and initial optimization studies on EtoBox?

N-Acetamideindolecarboxylic acid allosteric ‘finger-loop’ inhibitors of the hepatitis C virus NS5B polymerase: discovery and initial optimization studies by Pierre L. Beaulieu; Eric Jolicoeur; James Gillard; Christian Brochu; René Coulombe; Nathalie Dansereau; Jianmin Duan; Michel Garneau; Araz Jakalian; Peter Kühn; Lisette Lagacé; Steven LaPlante; Ginette McKercher; Stéphane Perrault; Martin Poirier; Marc-André Poupart; Timothy Stammers; Louise Thauvette; Bounkham Thavonekham; George Kukolj is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is N-Acetamideindolecarboxylic acid allosteric ‘finger-loop’ inhibitors of the hepatitis C virus NS5B polymerase: discovery and initial optimization studies about?

SAR studies at the N(1)-position of allosteric indole-based HCV NS5B inhibitors has led to the discovery of acetamide derivatives with good cellular potency in subgenomic replicons (EC(50) <200 nM). This class of inhibitors displayed improved physicochemical properties and favorable ADME-PK profiles over previously described analogs in this class.

Who reads N-Acetamideindolecarboxylic acid allosteric ‘finger-loop’ inhibitors of the hepatitis C virus NS5B polymerase: discovery and initial optimization studies?

Author

Pierre L. Beaulieu; Eric Jolicoeur; James Gillard; Christian Brochu; René Coulombe; Nathalie Dansereau; Jianmin Duan; Michel Garneau; Araz Jakalian; Peter Kühn; Lisette Lagacé; Steven LaPlante; Ginette McKercher; Stéphane Perrault; Martin Poirier; Marc-André Poupart; Timothy Stammers; Louise Thauvette; Bounkham Thavonekham; George Kukolj

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)

Published

2010

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)