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Dissecting the clinicopathologic, genomic, and immunophenotypic correlates of KRASG12D-mutated non-small-cell lung cancer by B. Ricciuti; J.V. Alessi; A. Elkrief; X. Wang; A. Cortellini; Y.Y. Li; V.R. Vaz; H. Gupta; F. Pecci; A. Barrichello; G. Lamberti; T. Nguyen; J. Lindsay; B. Sharma; K. Felt; S.J. Rodig; M. Nishino; L.M. Sholl; D.A. Barbie; M.V. Negrao; J. Zhang; A.D. Cherniack; J.V. Heymach; M. Meyerson; C. Ambrogio; P.A. Jänne; K.C. Arbour; D.J. Pinato; F. Skoulidis; A.J. Schoenfeld; M.M. Awad; J. Luo is a Medicine article available to read on EtoBox.

What is Dissecting the clinicopathologic, genomic, and immunophenotypic correlates of KRASG12D-mutated non-small-cell lung cancer about?

Background: Allele-specific KRAS inhibitors are an emerging class of cancer therapies. KRAS-mutant (KRAS MUT ) nonsmall-cell lung cancers (NSCLCs) exhibit heterogeneous outcomes, driven by differences in underlying biology shaped by co-mutations. In contrast to KRAS G12C NSCLC, KRAS G12D NSCLC is associated with low/never-smoking status and is largely uncharacterized. Patients and methods: Clinicopathologic and genomic information were collected from patients with NSCLCs harboring a KRAS mutation at the Dana-

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Author

B. Ricciuti; J.V. Alessi; A. Elkrief; X. Wang; A. Cortellini; Y.Y. Li; V.R. Vaz; H. Gupta; F. Pecci; A. Barrichello; G. Lamberti; T. Nguyen; J. Lindsay; B. Sharma; K. Felt; S.J. Rodig; M. Nishino; L.M. Sholl; D.A. Barbie; M.V. Negrao; J. Zhang; A.D. Cherniack; J.V. Heymach; M. Meyerson; C. Ambrogio; P.A. Jänne; K.C. Arbour; D.J. Pinato; F. Skoulidis; A.J. Schoenfeld; M.M. Awad; J. Luo

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Medicine (Health Sciences)