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Can I read Innovative Diagnostic Peptide‐Based Technologies for Cancer Diagnosis: Focus on EGFR‐Targeting Peptides on EtoBox?
Innovative Diagnostic Peptide‐Based Technologies for Cancer Diagnosis: Focus on EGFR‐Targeting Peptides by Mohammad Ahmadi; Yaghoub Ahmadyousefi; Zahra Salimi; Rasoul Mirzaei; Rezvan Najafi; Bagher Amirheidari; Fatemeh Rahbarizadeh; Javad Kheshti; Armin Safari; Meysam Soleimani is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Innovative Diagnostic Peptide‐Based Technologies for Cancer Diagnosis: Focus on EGFR‐Targeting Peptides about?
## Abstract Active targeting using biological ligands has emerged as a novel strategy for the targeted delivery of diagnostic agents to tumor cells. Conjugating functional targeting moieties with diagnostic probes can increase their accumulation in tumor cells and tissues, enhancing signal detection and, thus, the sensitivity of diagnosis. Due to their small size, ease of chemical synthesis and site‐specific modification, high tissue penetration, low immunogenicity, rapid blood clearance, low cost, and biosafety, peptides offer several advantages over antibodies and proteins in diagnostic applications. Epidermal growth factor receptor (EGFR) is one of the most promising cancer biomarkers for actively targeting diagnostic and therapeutic agents to tumor cells due to its active involvement and overexpression in various cancers. Several peptides for EGFR‐targeting have been identified in the last decades, which have been obtained by multiple means including derivation from natural proteins, phage display screening, positional scanning synthetic combinatorial library, and in silico screening. Many studies have used these peptides as a targeting moiety for diagnosing different cancers i
Who reads Innovative Diagnostic Peptide‐Based Technologies for Cancer Diagnosis: Focus on EGFR‐Targeting Peptides?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Mohammad Ahmadi; Yaghoub Ahmadyousefi; Zahra Salimi; Rasoul Mirzaei; Rezvan Najafi; Bagher Amirheidari; Fatemeh Rahbarizadeh; Javad Kheshti; Armin Safari; Meysam Soleimani
- Publisher
- Wiley
- Published
- 2022
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)