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Paraneoplastic Degeneration of the Substantia Nigra with Dystonia and Parkinsonism by Dr. Lawrence I. Golbe; Douglas C. Miller; Roger C. Duvoisin is a Medicine article available to read on EtoBox.

What is Paraneoplastic Degeneration of the Substantia Nigra with Dystonia and Parkinsonism about?

A 42-year-old woman suffered unexplained weight loss followed by action tremor and difficulty initiating gait. Three months after onset of s y m p toms, infiltrating ductal carcinoma of the breast, metastatic to liver and lymph nodes, was diagnosed and treated briefly with cyclophosphamide, methotrexate, and 5-flourouracil (SFU). Severe symmetric action and postural tremor with a myoclonic component developed, with minimal rest tremor, severe dysarthria and dysphagia, small-stepped and slightly ataxic gait progressing to a bedbound state, and severe widespread dystonic posturing. The latter began as a typical parkinsonian posture of trunk and upper extremities and progressed to a fixed and painful flexion of the elbows and wrists and extension of fingers and neck. Sinemet, anticholinergics, baclofen, diazepam, and plasmapheresis gave no benefit. The patient died of complications of immobility 5 months after neurologic symptom onset. Autopsy revealed many pigmentladen macrophages in substantia nigra and moderate loss of pigmented neurons. Inflammation, Lewy bodies, and tumor were absent. Cerebellar Purkinje cells were moderately depleted. Mild neuronal loss and gliosis were present

Who reads Paraneoplastic Degeneration of the Substantia Nigra with Dystonia and Parkinsonism?

Author

Dr. Lawrence I. Golbe; Douglas C. Miller; Roger C. Duvoisin

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0885-3185)

Published

1989

Language

EN

Field

Medicine (Health Sciences)