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Identification of the Osteopontin gene as a direct target of TP53 by Ichiro Morimoto; Yasushi Sasaki; Setsuko Ishida; Kohzoh Imai; Takashi Tokino is a Medicine article available to read on EtoBox.

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## Abstract The __TP53__ tumor suppressor gene regulates a number of genes that are involved in cell‐cycle inhibition, apoptosis, and maintaining genetic stability. Recently, two genes that have a role in immunosurveillance were identified as downstream targets of TP53. These genes, __TAP1__ and __fractalkine,__ may contribute to suppress tumor growth through host immunosurveillance. It has been reported that the mouse secreted phosphoprotein osteopontin (Opn) is one of the key cytokines for type 1 immune responses mediated by macrophages. It also was reported that Opn may play a role in suppressing tumor growth in vivo. Here we identified __Opn__ as a Tp53‐target gene using mRNA differential display analysis of embryonic fibroblasts from __Tp53__‐deficient mice. Furthermore, we found that __Opn__ expression was upregulated by DNA damage–induced Tp53 activity and by adenovirus‐mediated transfer of the human __TP53__ gene. In addition, a luciferase assay showed that the __Opn__ gene has a functional Tp53‐responsive element in its promoter region, and a chromatin immunoprecipitation assay confirmed interaction between the __Opn__ promoter and Tp53 protein in vivo. These results sugge

Who reads Identification of the Osteopontin gene as a direct target of TP53?

Author

Ichiro Morimoto; Yasushi Sasaki; Setsuko Ishida; Kohzoh Imai; Takashi Tokino

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); Wiley-Liss Inc; Wiley (ISSN 1045-2257)

Published

2002

Language

EN

Field

Medicine (Life Sciences)