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Utilization of Uniformly Labeled ^13^C‐Polyunsaturated Fatty Acids in the Synthesis of Long‐Chain Fatty Acids and Cholesterol Accumulating in the Neonatal Rat Brain by S. C. Cun-nane; S. C. R. Williams; J. D. Bell; S. Brookes; K. Craig; R. A. Iles; M. A. Crawford is a Neuroscience article available to read on EtoBox.
What is Utilization of Uniformly Labeled ^13^C‐Polyunsaturated Fatty Acids in the Synthesis of Long‐Chain Fatty Acids and Cholesterol Accumulating in the Neonatal Rat Brain about?
Abstract: Polyunsaturated fatty acids are needed for normal neonatal brain development, but the degree of conversion of the 18‐carbon polyunsaturated fatty acid precursors consumed in the diet to their respective 20‐and 22‐carbon polyunsaturates accumulating in the brain is not well known. In the present study, in vivo ^13^C nuclear magnetic resonance spectroscopy was used to monitor noninvasively the brain uptake and metabolism of a mixture of uniformly ^13^C‐enriched 16‐and 18‐carbon polyunsaturated fatty acid methyl esters injected intragastrically into neonatal rats. In vivo NMR spectra of the rat brain at postnatal days 10 and 17 had larger fatty acid signals than in uninjected controls, but changes in levels of individual fatty acids could not be distinguished. One day after injection of the U‐^13^C‐polyunsaturated fatty acid mixture, ^13^C enrichment (measured by isotope ratio mass spectrometry) was similar in brain phospholipids, free fatty acids, free cholesterol, and brain aqueous extract; ^13^C enrichment remained high in the phospholipids and cholesterol for 15 days. ^13^C enrichment was similar in the main fatty acids of the brain within 1 day of injection but 15 days
Who reads Utilization of Uniformly Labeled ^13^C‐Polyunsaturated Fatty Acids in the Synthesis of Long‐Chain Fatty Acids and Cholesterol Accumulating in the Neonatal Rat Brain?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- S. C. Cun-nane; S. C. R. Williams; J. D. Bell; S. Brookes; K. Craig; R. A. Iles; M. A. Crawford
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0022-3042)
- Published
- 1994
- Language
- EN
- Field
- Neuroscience (Life Sciences)