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Rapid Communication Muscle Mitochondrial ATP Production in Progressive Supranuclear Palsy by Donate A. Di Monte; Yadollah Harati; Joseph Jankovic; Martha S. Sandy; Sarah A. Jewell; J. William Langston is a Neuroscience article available to read on EtoBox.

What is Rapid Communication Muscle Mitochondrial ATP Production in Progressive Supranuclear Palsy about?

Abstract: Six patients with progressive supranuclear palsy (PSP) and 12 age‐matched disease‐free subjects participated in this study designed to compare rates of ATP production by intact mitochondria from biopsied skeletal muscle. When pyruvate and malate were used as metabolic substrates, rates of ATP production were 0.184 ± 0.025 μmol/min/U of citrate synthase (CS) activity (a mitochondrial marker) in control subjects and 0.131 ± 0.051 μmol/min/U of CS in PSP patients. In the presence of succinate, rates of ATP formation were 0.137 + 0.02 μmol/min/U of CS in controls and 0.109 ± 0.04 /4mUmol/min/U of CS in patients. With __N,N,N′,N′__‐tetramethyl‐__p__‐phenylenediamine (TMPD) and ascorbate, rates were 0.034 ± 0.008 μm Umol/min/U of CS in controls and 0.022 ± 0.01 μmol/min/U of CS in PSP subjects. Differences between the control and PSP populations reached statistical significance with pyruvate/malate and TMPD/ascorbate. No differences in either muscle histopathology or histochemistry were found between patient and control subjects. Results of this study suggest that oxidative phosphorylation defects occur in muscle mitochondria from patients with PSP.

Who reads Rapid Communication Muscle Mitochondrial ATP Production in Progressive Supranuclear Palsy?

Author

Donate A. Di Monte; Yadollah Harati; Joseph Jankovic; Martha S. Sandy; Sarah A. Jewell; J. William Langston

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0022-3042)

Published

1994

Language

EN

Field

Neuroscience (Life Sciences)