Can I read Genetic alterations of the putative envelope proteins encoding region of the hepatitis C virus in the progression to relapsed phase from acute hepatitis: Humoral immune response to hypervariable region 1 on EtoBox?

Genetic alterations of the putative envelope proteins encoding region of the hepatitis C virus in the progression to relapsed phase from acute hepatitis: Humoral immune response to hypervariable region 1 by Hitomi Sekiya; Nobuyuki Kato; Yuko Ootsuyama; Takahide Nakazawa; Katsumi Yamauchi; Kunitada Shimotohno is a Medicine article available to read on EtoBox.

What is Genetic alterations of the putative envelope proteins encoding region of the hepatitis C virus in the progression to relapsed phase from acute hepatitis: Humoral immune response to hypervariable region 1 about?

Hypervariable region I (HVRI) of the putative second envelope glycoprotein (gp70) of hepatitis C virus (HCV) undergoes sequential alterations at intervals of several months during the chronic phase of hepatitis. To evaluate the implications of sequence variability in HVRl of HCV, we investigated the sequence variability of the whole envelope-protein(gp35 and gp70)-coding regions of HCV genome derived from patient M in acute and relapsed phases (8-month interval) of hepatitis. From this analysis, we found that a Leu (position 405) in HVRl substituted to Pro, and that 4 additional substitutions could be detected in gp70 during the relapsed phase. Sequence-specific antibody against HVRl derived from patient M was first detected in the serum at 8 months after the onset of hepatitis, but no other specific antibodies against peptides containing aminoacid position(s) substituted in regions other than HVRl could be detected. Epitope mapping using the sequence of HVRl derived from the acute phase of hepatitis was also performed, and a B-cell epitope (positions 397 to 407) of I I amino acids was identified. However, the Pro variant at position 405 did not display an escape pattern from the a

Who reads Genetic alterations of the putative envelope proteins encoding region of the hepatitis C virus in the progression to relapsed phase from acute hepatitis: Humoral immune response to hypervariable region 1?

Author

Hitomi Sekiya; Nobuyuki Kato; Yuko Ootsuyama; Takahide Nakazawa; Katsumi Yamauchi; Kunitada Shimotohno

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

1994

Language

EN

ISBN

9782910570507

Field

Medicine (Health Sciences)