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This study investigates the long-term effects of intra-hippocampal cis-P tau microinjection on behavior and synaptic plasticity in mice, revealing significant impairments in learning and memory at 7 months post-injection. The results indicate disrupted long-term potentiation and a notable decrease in neuron survival in the dorsal hippocampus, contributing to the observed cognitive deficits. These findings suggest that cis-P tau accumulation may play a critical role in the development of Alzheimer

Author

iremnurormanci

Language

EN