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Comparison of Immunosuppressive and Immunomodulatory Cells in Keratoacanthoma and Cutaneous Squamous Cell Carcinoma by Y Kambayashi; T Fujimura; S Aiba is a Medicine article available to read on EtoBox.

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An imbalance of immunosuppressive and immunomodulatory cells plays an important role in inhibiting the anti-tumour immune response in a tumour-bearing host. Among such cells, regulatory T cells (Tregs), together with immunosuppressive macrophages, such as CD163\* M2 macrophages, play roles in maintaining the tumour microenvironment. In contrast, interleukin-27 (IL-27) induces STATl and STAT3 activation, thus resulting in the enhancement of naive CD4 T-cell proliferation, the promotion of early Thl differentiation, and the induction of the anti-tumour immune response. The purpose of this study was to investigate the involvement of immunosuppressive cells, such as Tregs and CD163\* macrophages, as well as immunomodulatory cells (i.e. IL-27-producing cells) in keratoacanthoma (KA) and invasive squamous cell carcinoma (SCC). We also examined the presence of CD3\* Foxp3\* Tregs cells in lesional skin from 10 patients with KA and 18 patients with SCC. Increased numbers of CD3\* Foxp3'^ Tregs were observed in SCC compared with KA. In parallel with Tregs, higher numbers of CD163\* macrophages and MMP-9\* cells were detected only in SCC. In contrast, IL-27-producing cells were increased onl

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Author

Y Kambayashi; T Fujimura; S Aiba

Publisher

Medical Journals Sweden AB

Published

2013

Language

EN

Field

Medicine (Health Sciences)