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Long-term CIN3+ risk of HPV positive women after triage with FAM19A4/miR124-2 methylation analysis by Stèfanie Dick; Wieke W. Kremer; Lise M.A. De Strooper; Birgit I. Lissenberg-Witte; Renske D.M. Steenbergen; Chris J.L.M. Meijer; Johannes Berkhof; Daniëlle A.M. Heideman is a Medicine article available to read on EtoBox.
What is Long-term CIN3+ risk of HPV positive women after triage with FAM19A4/miR124-2 methylation analysis about?
## Objective: This study evaluates the long-term risk for cervical intraepithelial neoplasia grade 3 or worse (cin3+) among hpv positive women triaged with fam19a4/mir124-2 methylation analysis. ## Methods: In a post hoc analysis, data on fam19a4/mir124-2 methylation, cytology, and hpv16/18 genotyping of hpv positive women (n = 1025) from a large population-based screening cohort with 14-year follow-up were evaluated. cumulative cin3+ incidences over 3 screening rounds (5-year intervals) of 4 triage strategies were compared: fam19a4/mir124-2 methylation analysis, cytology, hpv16/18 genotyping with fam19a4/mir124-2 methylation, and hpv16/18 genotyping with cytology. ## Results: Kaplan-meier estimates of 14-year cumulative cin3+ incidence of hpv positive women with a negative methylation and a negative cytology triage test were comparable (16.3% and 15.6%, respectively). the cumulative cin3+ incidence of methylation positive and cytology positive women were 39.8% and 46.5%, respectively. hpv16/18 genotyping with methylation and hpv16/18 genotyping with cytology resulted in the lowest 14-year cumulative cin3+ incidence among triage negative women (10.7% and 10.0%, respectively), but c
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- Author
- Stèfanie Dick; Wieke W. Kremer; Lise M.A. De Strooper; Birgit I. Lissenberg-Witte; Renske D.M. Steenbergen; Chris J.L.M. Meijer; Johannes Berkhof; Daniëlle A.M. Heideman
- Publisher
- Elsevier BV
- Published
- 2019
- Language
- EN
- Field
- Medicine (Health Sciences)