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What is OTOP1 Channel: Ammonium Taste Sensor about?

1) The proton channel OTOP1, which is expressed in sour taste receptor cells, functions as a sensor for ammonium chloride (NH4Cl). 2) Extracellular NH4Cl evoked large currents in cells expressing OTOP1, correlating with its ability to raise intracellular pH. 3) Mice lacking a functional OTOP1 channel showed strongly attenuated or eliminated taste responses to NH4Cl from isolated taste cells and gustatory nerves, as well as abolished behavioral aversion to NH4Cl.

Author

Elton Matsushima

Language

EN