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Expression of the Mouse Interleukin-2 Receptor γ Chain in Various Cell Populations of the Thymus and Spleen by Motonari Kondo; Yoichi Ohashi; Kohtaro Tada; Masataka Nakamura; Kazuo Sugamura is a Immunology and Microbiology article available to read on EtoBox.

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## Abstract Expression of the γ chain, which is shared among functional receptor complexes for interleukin (IL)‐2, IL‐4 and IL‐7, was examined with hematopoietic cells in mouse thymus and spleen by flow cytometry. The γ chain was expressed in cell populations from the spleen. Stimulation with concanavalin A and lipopolysaccharide caused fluctuation in expression of the γ chain in T and B cells, respectively. T lineage cells developing in the adult thymus expressed the γ chain. Fetal thymus at day 15 contained mostly immature thymocytes, which also expressed the γ chain. These results demonstrate that the γ chains is widely expressed in T lineage cells, probably indicating that the γ chain plays a role not only in the proliferation of mature hematopoietic cells but also in the development of immature cells through signal transduction as a common receptor subunit for multiple cytokines.

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Author

Motonari Kondo; Yoichi Ohashi; Kohtaro Tada; Masataka Nakamura; Kazuo Sugamura

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley (ISSN 0014-2980)

Published

1994

Language

EN

Field

Immunology and Microbiology (Life Sciences)