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Long-Range Gene Regulation in Cancers by Maricruz García is a document available to read on EtoBox.

What is Long-Range Gene Regulation in Cancers about?

1) Steroid receptors like the glucocorticoid receptor interact with and modulate long-range chromatin interactions in response to hormones. 2) Hormone activation of steroid receptors reshapes the 3D genome structure by altering long-range interactions genome-wide and transitioning chromatin from active to repressed compartments. 3) Mutations disrupting the 3D genome organization are associated with hormone-dependent cancers by dysregulating gene expression through altered long-range interactions.

Author

Maricruz García

Language

EN