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Can I read Brain kinetics of methylphenidate (Ritalin) enantiomers after oral administration on EtoBox?
Brain kinetics of methylphenidate (Ritalin) enantiomers after oral administration by Yu‐Shin Ding; S. John Gatley; Panayotis K. Thanos; Colleen Shea; Victor Garza; Youwen Xu; Pauline Carter; Payton King; Don Warner; Nicholas B. Taintor; Daniel J. Park; Bea Pyatt; Joanna S. Fowler; Nora D. Volkow is a Neuroscience article available to read on EtoBox.
What is Brain kinetics of methylphenidate (Ritalin) enantiomers after oral administration about?
Methylphenidate (MP) (Ritalin) is widely used for the treatment of attention deficit hyperactivity disorder (ADHD). It is a chiral drug, marketed as the racemic mixture of d- and l-threo enantiomers. Our previous studies (PET and microdialysis) in humans, baboons, and rats confirm the notion that pharmacological specificity of MP resides predominantly in the d-isomer. A recent report that intraperitoneally (i.p.) administered l-threo-MP displayed potent, dose-dependent inhibition of cocaine- or apomorphine-induced locomotion in rats, raises the question of whether l-threo-MP has a similar effect when given orally. It has been speculated that l-threo-MP is poorly absorbed in humans when it is given orally because of rapid presystemic metabolism. To investigate whether l-threo-MP or its metabolites can be delivered to the brain when it is given orally, and whether l-threo-MP is pharmacologically active. PET and MicroPET studies were carried out in baboons and rats using orally delivered C-11-labeled d- and l-threo-MP ([methyl-(11)C]d-threo-MP and [methyl-(11)C]l-threo-MP). In addition, we assessed the effects of i.p. l-threo-MP on spontaneous and cocaine-stimulated locomotor activity
Who reads Brain kinetics of methylphenidate (Ritalin) enantiomers after oral administration?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Yu‐Shin Ding; S. John Gatley; Panayotis K. Thanos; Colleen Shea; Victor Garza; Youwen Xu; Pauline Carter; Payton King; Don Warner; Nicholas B. Taintor; Daniel J. Park; Bea Pyatt; Joanna S. Fowler; Nora D. Volkow
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0887-4476)
- Published
- 2004
- Language
- EN
- Field
- Neuroscience (Life Sciences)