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Diabetes-associated genetic variation in TCF7L2 alters pulsatile insulin secretion in humans by Laurenti, Marcello C.; Dalla Man, Chiara; Varghese, Ron T.; Andrews, James C.; Rizza, Robert A.; Matveyenko, Aleksey; De Nicolao, Giuseppe; Cobelli, Claudio; Vella, Adrian is a Immunology and Microbiology article available to read on EtoBox.
What is Diabetes-associated genetic variation in TCF7L2 alters pulsatile insulin secretion in humans about?
BACKGROUNDMetabolic disorders such as type 2 diabetes have been associated with a decrease in insulin pulse frequency and amplitude. We hypothesized that the T allele at rs7903146 in TCF7L2, previously associated with β cell dysfunction, would be associated with changes in these insulin pulse characteristics.METHODSTwenty-nine nondiabetic subjects (age 46 ± 2, BMI 28 ± 1 kg/m2) participated in this study. Of these, 16 were homozygous for the C allele at rs7903146 and 13 were homozygous for the T allele. Deconvolution of peripheral C-peptide concentrations allowed the reconstruction of portal insulin secretion over time. These data were used for subsequent analyses. Pulse orderliness was assessed by approximate entropy (ApEn), and the dispersion of insulin pulses was measured by a frequency dispersion index (FDI) after a Fast Fourier Transform (FFT) of individual insulin secretion rates.RESULTSDuring fasting conditions, the CC genotype group exhibited decreased pulse disorderliness compared with the TT genotype group (1.10 ± 0.03 vs. 1.19 ± 0.04, P = 0.03). FDI decreased in response to hyperglycemia in the CC genotype group, perhaps reflecting less entrainment of insulin secretion d
Who reads Diabetes-associated genetic variation in TCF7L2 alters pulsatile insulin secretion in humans?
It is typically read by researchers, students, and practitioners in Immunology and Microbiology.
- Author
- Laurenti, Marcello C.; Dalla Man, Chiara; Varghese, Ron T.; Andrews, James C.; Rizza, Robert A.; Matveyenko, Aleksey; De Nicolao, Giuseppe; Cobelli, Claudio; Vella, Adrian
- Publisher
- American Society for Clinical Investigation; The American Society for Clinical Investigation (ISSN 2379-3708)
- Published
- 2020
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)