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Nano-selenium Alleviates Cadmium-induced Cerebellar Injury by Activating Metal Regulatory Transcription Factor 1 Mediated Metal Response by Shao-Shuai Bi; Milton Talukder; Hai-Tao Jin; Mei-Wei Lv; Jing Ge; Cong Zhang; Jin-Long Li is a Agricultural and Biological Sciences article available to read on EtoBox.
What is Nano-selenium Alleviates Cadmium-induced Cerebellar Injury by Activating Metal Regulatory Transcription Factor 1 Mediated Metal Response about?
This study aims to investigate the role of metal regulatory transcription factor 1 (MTF1)-mediated metal response in cadmium (Cd)-induced cerebellar injury, and to evaluate the antagonistic effects of nano-selenium (Nano-Se) against Cd toxicity. A total of 80 chicks (1 d old, male, Hy-Line Variety White) were randomly allocated to 4 treatment groups for 3 months: the control group (fed with a basic diet, __n__ = 20), the Nano-Se group (basic diet with 1 mg/kg nano-Se 1 mg/kg Nano-Se in basic diet, __n__ = 20), the Nano-Se + Cd group (basic diet with 1 mg/kg Nano-Se and 140 mg/kg CdCl~2~, __n__ = 20) and the Cd group (basic diet with 140 mg/kg CdCl~2~ , __n__ = 20). The results of the experiment showed that the Purkinje cells were significantly decreased with their degradation and indistinct nucleoli after Cd exposure. Moreover, exposure to Cd caused a significant accumulation of Cd and cupper. However, the contents of Se, iron, and zinc were decreased, thereby disturbing the metal homeostasis in the cerebellum. The Cd exposure also resulted in high levels of malondialdehyde (MDA) and down regulation of selenoprotein transcriptome. Furthermore, the expressions of __MTF1__, metalloth
Who reads Nano-selenium Alleviates Cadmium-induced Cerebellar Injury by Activating Metal Regulatory Transcription Factor 1 Mediated Metal Response?
It is typically read by researchers, students, and practitioners in Agricultural and Biological Sciences.
- Author
- Shao-Shuai Bi; Milton Talukder; Hai-Tao Jin; Mei-Wei Lv; Jing Ge; Cong Zhang; Jin-Long Li
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Agricultural and Biological Sciences (Life Sciences)