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Can I read Combination of Cyclosporine A and Levosimendan Induces Cardioprotection under Acute Hyperglycemia on EtoBox?
Combination of Cyclosporine A and Levosimendan Induces Cardioprotection under Acute Hyperglycemia by Carolin Torregroza; Birce Yueksel; Raphael Ruske; Martin Stroethoff; Annika Raupach; André Heinen; Markus W. Hollmann; Ragnar Huhn; Katharina Feige is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Combination of Cyclosporine A and Levosimendan Induces Cardioprotection under Acute Hyperglycemia about?
Prognosis of patients with myocardial infarction is detrimentally affected by comorbidities like diabetes mellitus. In the experimental setting, not only diabetes mellitus but also acute hyperglycemia is shown to hamper cardioprotective properties by multiple pharmacological agents. For Levosimendan-induced postconditioning, a strong infarct size reducing effect is demonstrated in healthy myocardium. However, acute hyperglycemia is suggested to block this protective effect. In the present study, we investigated whether (1) Levosimendan-induced postconditioning exerts a concentration-dependent effect under hyperglycemic conditions and (2) whether a combination with the mitochondrial permeability transition pore (mPTP) blocker cyclosporine A (CsA) restores the cardioprotective properties of Levosimendan under hyperglycemia. For this experimental investigation, hearts of male Wistar rats were randomized and mounted onto a Langendorff system, perfused with Krebs-Henseleit buffer with a constant pressure of 80 mmHg. All isolated hearts were subjected to 33 min of global ischemia and 60 min of reperfusion under hyperglycemic conditions. (1) Hearts were perfused with various concentration
Who reads Combination of Cyclosporine A and Levosimendan Induces Cardioprotection under Acute Hyperglycemia?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Carolin Torregroza; Birce Yueksel; Raphael Ruske; Martin Stroethoff; Annika Raupach; André Heinen; Markus W. Hollmann; Ragnar Huhn; Katharina Feige
- Publisher
- MDPI AG
- Published
- 2021
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)