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Losartan modulates brain inflammation and improves mood disorders and memory impairment induced by innate immune activation: The role of PPAR-γ activation by Hossein Salmani; Mahmoud Hosseini; Yousef Baghcheghi; Reyhaneh Moradi-Marjaneh; Amin Mokhtari-Zaer is a Immunology and Microbiology article available to read on EtoBox.
What is Losartan modulates brain inflammation and improves mood disorders and memory impairment induced by innate immune activation: The role of PPAR-γ activation about?
In recent years, the role of angiotensin II (Ang II) and Ang II type 1 receptor (AT1) in the crosstalk between the immune system and the central nervous system has received more attention. The present study aimed to investigate the role of losartan, an AT1 receptor blocker, in the modulation of long-lasting adverse effects of repeated systemic lipopolysaccharide (LPS) injection in the brain function. For this purpose, 110 male BALB/c mice were administrated LPS (250 μg/kg) intraperitoneally (i.p.) for seven consecutive days. Mice were i.p. injected with losartan (1 and 3 mg/kg) three days before and during the LPS injection. To determine the role of PPAR-γ activation in the protective actions of losartan, GW9662, a PPAR-γ antagonist, was also co-administrated with losartan. Then, behavioral tests, including Morris water maze (MWM), novel object recognition test, passive avoidance, forced swim test (FST), elevated plus maze, and marble burying task, were conducted. The results demonstrated that losartan improved learning and memory impairment, attenuated anxiety-like behaviors, modulated brain inflammation and oxidative stress, and decreased amyloid-β accumulation. Losartan was unab
Who reads Losartan modulates brain inflammation and improves mood disorders and memory impairment induced by innate immune activation: The role of PPAR-γ activation?
It is typically read by researchers, students, and practitioners in Immunology and Microbiology.
- Author
- Hossein Salmani; Mahmoud Hosseini; Yousef Baghcheghi; Reyhaneh Moradi-Marjaneh; Amin Mokhtari-Zaer
- Publisher
- Elsevier BV
- Published
- 2019
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)