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Synthesis of standards of the most important markers of Leuckart p-methoxymethamphetamine (PMMA) by J Kochana; J Wilamowski; A Parczewski; M Surma is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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The synthesis of characteristic markers of PMMA obtained by Leuckart method was described. The effectiveness of a procedure of SPE/TLC screening profiling of impurities was studied on the basis of selected impurities. The influence of glucose (a drug diluent) on the profile quality was investigated. The intermediate product (characteristic for the Leuckart synthesis) N-formyl-p-methoxymethamphetamine (1) and by-products: N-formyl-p-methoxyamphetamine (2), p-methoxyamphetamine (3), N,N-dimethyl-p-methoxyamphetamine (4), (RS) and (RR/SS) diastereoisomers of bis(1-methyl-2-(4-methoxyphenyl)ethyl)amine (meso-5 and rac-5), (RS) and (RR/SS) diastereoisomers of N-methyl-bis(1-methyl-2-(4-methoxyphenyl)ethyl)amine (meso-6 and rac-6), N-methyl-1,3-bis(4-methoxyphenyl)propane-2-amine (7) were synthesized. The substrate p-methoxyphenylacetone and the impurities 1 and 4 were used in the study of influence of experimental conditions and glucose on the profiling process and results. The experiments were carried out according to a 2(4) factorial design. The proposed criterions of the profile quality are based on matrix presentation of TLC patterns. They take into account the number of spots revea

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Author

J Kochana; J Wilamowski; A Parczewski; M Surma

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0379-0738)

Published

2003

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)