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What is TCRβ Profiling Enhances Neoantigen Prediction about?
This research article introduces a novel machine learning algorithm that integrates T cell receptor β chain (TCRβ) profiling with peptide-human leukocyte antigen (pHLA) binding data to enhance neoantigen prediction and prioritization in colorectal cancer. The study demonstrates that this combined approach improves specificity and sensitivity in identifying immunogenic neoantigens, which are crucial for effective cancer immunotherapy. Experimental validation through ELISpot assays confirms the efficacy of th
- Author
- Ngoc Dung
- Language
- EN